Online | 21-23 June 2021 All times shown in the programme are
Right now, it is HH:mm (dd mmm 'YY) in Florence.
Session 1: Lactate and tumor microenvironment
Chairs: Pierre Sonveaux (UCL, Belgium), Andrea Morandi (University of Florence, Italy)
14:00-14:15
Opening remarks
14:15-14:45
Joshua Rabinowitz
Sources and sinks of circulating lactate
14:50-15:20
Carlos Carmona Fontaine
Spatial heterogeneity in Lactate metabolism of Tumor-Associated Macrophages
15:25-15:55
Gerhard Christofori
Lactate and anti-oxidant pathway underlie resistance to targeted therapy
16:00-16:20
Break
16:20-16:50
Paola Chiarugi
Lactate-driven metabolic and epigenetic prostate tumor-stroma crosstalk
16:50-17:20
Alpaslan Tasdogan
Metabolic heterogeneity confers differences in melanoma metastatic potential
17:25-17:55
Guillem Pratx
Tumor lactate and FDG uptake—two sides of the same coin?
18:00-19:00
Poster session
Session 2: Lactate & immunity
Chairs: Luigi Ippolito (University of Florence, Italy), Silvia Giordano (University of Turin, Italy)
14:00-14:30
Jacques Pouyssegur
"Warburg effect”, acidic stress and therapeutics options
14:35-15:05
Marina Kreutz
Lactate-a metabolic immune checkpoint in the tumor environment
15:10-15:25
Selected talk 1 • Luigi Ippolito
Stromal lactate promotes prostate cancer aggressiveness by enhancing collagen-dependent cancer cell colonization
15:25-15:40
Selected talk 2 • Nunzio Vicario
Lactate modulates Microglia M2 polarization via IGFBP6 expression and remodels tumor microenvironment in Glioblastoma
15:40-15:55
Break
16:00-16:30
Federica Benvenuti
Lactate affects presentation of tumor antigens by dendritic cells
16:35-17:05
Claudio Mauro
Lactate-mediated regulation of the adaptive immunity in the inflammatory microenvironment
17:10-17:25
Selected talk 3 • Jing Zhang
Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization
17:30-17:40
Break
17:40-18:10
Greg Delgoffe
Lactate-mediated metabolic symbiosis between the tumor microenvironment and regulatory T cells
Session 3: Lactate: signaling and targeting
Chairs: Elisa Giannoni (University of Florence, Italy), Claudio Mauro (University of Birmingham, UK)
14:00-14:30
Yingming Zhao
Histone lactylation: a new epigenetic modification
14:35-15:05
Madesh Muniswamy
Unlocking Lactate's new potentials as a modulator of cellular ion homeostasis
15:10-15:20
Break
15:20-15:50
Olivier Feron
Lactate transport: how to block it without MCT inhibitors?
15:55-16:25
Linda H. Bergersen
Lactate receptor HCAR1 and signaling
16:30-16:40
Break
16:40-17:10
Don Gary Benjamin
Dual inhibition of the lactate transporters MCT1 and MCT4 by syrosingopine as a treatment modality for cancer
17:15-17:45
Vadivel Ganapathy
Autocrine and paracrine functions of lactic acid in cancer cells
17:50-18:20
Simona Corso
Lactate and non-cell autonomous resistance to EGFR/MET therapy
18:20-18:30
Break
18:30-19:00
Pierre Sonveaux
Lactate signals pseudohypoxia in cancer
19:00
Closing remarks
